Machine learning-guided drug repurposing for targeting PDK1 in breast cancer treatment
The phosphoinositide 3-kinase (PI3K)/3-phosphoinositide-dependent protein kinase-1 (PDK1)/protein kinase B (AKT) signaling axis is dysregulated in breast cancer progression and therapeutic resistance. In this study, an integrated computational workflow was developed to prioritize FDA-approved drugs as potential PDK1-ta...
Srinivas Ganjipete, Bandral Sunil Kumar, Basavana Gowda Hosur Dinesh et al.
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