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Author

Seizo Koshiba

2 papers indexed here

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Open access Sep 2026

Ferroptosis regulates metabolic inflammation-driven tumorigenesis in obesity-related gastric cancer.

Cotreatment with HFD and GSK may promote SCJ tumor progression by suppressing ferroptosis through intratumoral NRF2 signaling and dysbiosis-related metabolites, indicating a negative role of PPAR-δ signaling on MetS-related SCJ tumorigenesis.

Mizuki Tanabe, K. Uno, Toru Tamahara et al. · 0 citations
Open access Sep 2026

Inter-domain distance analysis reveals conformational changes in the Keap1-Nrf2 stress sensor system

The Keap1-Nrf2 system plays a central role in cellular defense against oxidative stress. Structural information on full-length Keap1 is essential for understanding the molecular basis of this regulation. However, its overall architecture has remained elusive due to pronounced conformational flexibility. In this study,...

Ritsumi Saito, Takeshi Kawabata, S. Yamashita et al. · 0 citations

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