Seijo Uchijima

Arylacetamide deacetylase plays a protective role against amodiaquine-induced liver injury by suppressing ferroptosis.

Amodiaquine (AQ), an antimalarial drug, is metabolized by cytochrome P450 3A4 (CYP3A4) to quinoneimine forms, which are proposed to cause liver injury; however, the underlying mechanism remains unclear. Ferroptosis, a type of regulated cell death driven by iron-dependent lipid peroxidation, has been implicated in certa...