ABSTRACT G protein‐coupled receptors (GPCRs) constitute the largest family of drug targets, acting through heterotrimeric G proteins. Agonist bound GPCRs promote GDP release from G proteins allowing their activation upon GTP binding. Here, we analyze this process with innovative tools that detect the main states of nat...
Alexandre Bouyssou, Melinda Diniz da Silva, Julien Soulé et al.· Advancement of science· 0 citations
Atypical chemokine receptor 1 (ACKR1) is one of the most promiscuous receptors in the human chemokine system, engaging structurally diverse chemokines through a conformationally flexible N-terminal tail. This same interface is exploited by pathogens, including Plasmodium vivax and Staphylococcus aureus (SA), via a comp...
A. Fouillen, Élodie Logerot, Zainab Ammar et al.· bioRxiv· 0 citations
A simple and highly sensitive method allowing cell surface expression of a large diversity of target receptors and recording in real-time, currents generated by neo-formed pores is developed, able to elucidate the kinetics of pore formation, the limiting role of receptors in this process, and propose a complementary mo...
Laura Lemel, Simon Harris, Guillaume Audic et al.· bioRxiv· 0 citations
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