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Sebastian W. Ober

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#machine learning Mar 2026

How to make the most of your masked language model for protein engineering

This work proposes a flexible, effective sampling method for masked language models (MLMs), and reports results from an extensive in vitro head-to-head evaluation for the antibody engineering setting, revealing that the choice of sampling method can have a substantial impact, motivating future research into this under-...

Calvin McCarter, Nicholas Bhattacharya, Sebastian W. Ober et al. · arXiv.org · 1 citation