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Sebastian Hiller

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#protein folding Open access Oct 2026

Multi-Field CEST NMR Reconstructs a Protein Folding Landscape

It is shown that, in the presence of rapid “minor-exchange”, the apparent minor-state chemical shift obtained from two-state fits varies systematically with the static magnetic field, B0, and this field dependence is exploited to develop a nonperturbative, multi-field CEST strategy that distinguishes otherwise degenera...

V. P. Tiwari, Laetitia Rožić, Sebastian Hiller · 0 citations
#protein folding Open access Sep 2026

A High-Throughput Assay to Identify Specific Nascent Chain Inhibitors

“Undruggable” proteins without surface-accessible binding sites pose significant challenges to target-based drug discovery. Innovative approaches are needed to tackle these proteins. One promising strategy is targeting them in their nascent chain form at the ribosome, where they have a different conformation than in th...

P. Fischer, Sebastian Hiller · 0 citations

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