Author

Sean A. Burnap

2 papers indexed here

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Open access Sep 2026

An integrated mass spectrometry strategy for quantifying the proteoform diversity of the extensively modified O-glycoprotein Osteopontin

O-glycosylation is among the most abundant and structurally diverse post-translational modifications in eukaryotes, yet its heterogeneity renders O-glycoproteins exceptionally difficult to characterize. To overcome these challenges, we have developed an integrated mass spectrometry (MS) strategy to define the proteofor...

K. Zouboulis, Jack L. Bennett, Leonard A. Daly et al. · bioRxiv · 0 citations

Open access Oct 2026

Mechanism of spike opening in a mammalian gammacoronavirus

Coronavirus spike proteins mediate receptor binding and fusion and are key determinants of viral host range. To bind protein receptors, some CoV spikes undergo conformational changes termed opening, which expose the receptor-binding surface. Yet, the prerequisites and mechanism of spike opening remain poorly understood...

John D. Clarke, Michalina Grabias, Antonio di Maio et al. · bioRxiv · 0 citations