It is argued that cell segmentation for spatial pathology should be evaluated not only by boundary and instance accuracy, but also by preservation of the biological relationships that downstream analyses are intended to measure.
Nevenka Dimitrova, Marjan Stoimchev, A. Filliol et al.· bioRxiv· 0 citations
Scientific imaging is undergoing a fundamental transformation. Advances in multiplex immunofluorescence, computational pathology, and electron microscopy now enable observation of biological and physical systems at unprecedented spatial resolution. Rather than simply classifying known objects, these data offer the oppo...
Marjan Stoimchev, Monu Verma, A. Filliol et al.· bioRxiv· 0 citations
Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is unclear. Here, we show that elevated serum hepcidin is associated with reduced survival and decreased intratumoral CD8+ T...
J. Schoenfeld, Jahi J. Noel, Christopher S. McGinnis et al.· bioRxiv· 0 citations
It is shown that P-selectin is expressed by a subset of senescent-like cells in fibrotic tissues and tumors, which establishes SMNPs as a generalizable strategy to target pathogenic senescent cell subsets across fibrosis and cancer.
Clemens Hinterleitner, Valentin J. A. Barthet, Hailey V. Goldberg et al.· Science· 1 citation
A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.
Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al.· bioRxiv· 0 citations
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