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Scott P. Allen

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Open access Sep 2026

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

The findings indicate that TDP43 dysfunction drives impairment of ADA-mediated purine metabolism in vitro, leading to downstream effects that include DNA damage, likely through inhibition of DNA repair mechanisms, and the induction of cellular senescence.

Benjamin J. Hall, Yasmina M. Ebrahim, Joanne L. Sharpe et al. · 0 citations

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