Synthesis of α-Halophosphonates via Copper-Catalyzed Atom Transfer Radical Addition.
α-Substituted alkylphosphonates and phosphates have broad utility in the pharmaceutical, agrochemical, and commodity chemical industries. Herein, we present the copper-catalyzed atom transfer radical addition (ATRA) of alkyl halides to alkenylphosphonates for the synthesis of α-halophosphonates enabled by 1,1'-azobis(c...