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Saruby Sharma

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Open access Sep 2026

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase–nuclease coupling

The cryo-EM structure of the complete human mitochondrial RNA degradosome bound to RNA is reported and reveals an asymmetric heteropentamer composed of a SUV3 dimer and the trimeric PNPase, revealing a mode of helicase–nuclease coupling distinct from other RNA degradation machineries.

P. F. V. Do Prado, Saruby Sharma, Arjun Bhatta et al. · 0 citations

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