Implementation of DPYD genetic testing at a safety net oncology clinic.
628 Background: DPYD gene variants are associated with severe, potentially fatal toxicity from fluoropyrimidines (5-fluorouracil and capecitabine). Approximately 4-8% of the population carries deleterious variants affecting dihydropyrimidine dehydrogenase (DPD) activity. In October 2025, the FDA issued a black...