Author

Sarah T. Diepstraten

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Open access Sep 2026

A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Partita, a next-generation mouse whole-genome CRISPRa sgRNA platform, designed for unparalleled efficiency in gene activation studies, is introduced, unlocking new avenues for functional genomics and expanding the toolkit for discovering key drivers of biological processes across diverse research fields.

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts et al. · Science Advances · 0 citations

Open access Sep 2026

γδ T cells modulate anti-tumor immunity in small cell lung cancer.

Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigenetic silencing of MHC-I. Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes...

Jin Ng, Yue You, Tina Zhang et al. · Cancer Cell · 0 citations