Open access
Oct 2026
SETDB1 preferentially silences evolutionarily young retroelements.
Transposable elements (TEs) are epigenetically silenced through multiple mechanisms, including heterochromatin formation and DNA methylation. Prior studies have implicated SETDB1 and the Human Silencing Hub (HUSH) complex in heterochromatin formation-based TE repression, but precise characterization of repeat subclass...
Bercin K. Cenik, Si-Mai Wang, Marta Iwanaszko et al.
· Proceedings of the National... · 0 citations