Author

Sára Szádocka

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Open access Sep 2026

Structural and functional remodeling of large-scale cardiac tubes.

The functionality of tissue-engineered cardiac constructs using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is challenged by the cells' immature state. To promote cell and tissue maturation, co-culture approaches, mechanical, electrical and topographical stimuli have been applied. Here, large...

Sara Szadocka, Jana Teske, A. Franke et al. · Biofabrication · 0 citations

#protein folding Open access Aug 2026

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantat...

I. Gruh, Andreas Martens, S. Cebotari et al. · Nature Communications · 0 citations