Open access
Aug 2026
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
It is suggested that histone H3.3 K27M mutations drive diffuse midline glioma by ablating intrinsic regional differences in oligodendrocyte development, selectively expanding immature oligodendrocyte precursor cell populations in the brainstem while disrupting normal differentiation programs.
Jared M. Andrews, K. Budd, C. Kwon et al.
· Nature Communications · 0 citations