Sanyukta Darnal

Harnessing chirality for enhanced stability: An all-D protease resistant antimicrobial peptide active against drug-resistant skin bacteria.

The increasing prevalence of antimicrobial resistance has driven the search for new therapeutic alternatives to conventional antibiotics. Here, we improved the proteolytic stability of the archaeal antimicrobial peptide VLL28 by bioinformatically guiding sequence optimization, integrating truncation, charge-modifying m...