Sanni Översti

From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses

A practical framework linking sites, structure, and serology for viruses in which antigenic evolution is a major component of immune escape and lineage turnover is outlined and how integrating genomic surveillance data, phylogenetics, structural analysis, and predictive modeling could support more prospective variant assessment and improved vaccine and therapeutic design is discussed.