Author

Sanjeev S. Ranade

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Open access Sep 2026

Autophagy Flux Is Remodeled Sex‐ and Cell Type‐Specifically During Human Aging, and Is Linked to Reduced Physical Function in Older Adults

ABSTRACT Autophagy is widely proposed to decline with age; however, direct evidence across human cell types remains limited. Moreover, it is unclear whether age‐associated changes in autophagy‐gene transcription are accompanied by corresponding changes in autophagic activity, and whether autophagic activity relates to...

Tatiana M. Moreno, Stephanie R. Heimler, Ryan J. Moran et al. · Aging Cell · 0 citations

Open access Sep 2026

A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition

Cardiac regeneration is limited in the adult mammalian heart because of restricted cardiomyocyte proliferation and persistent fibrosis. We previously demonstrated that transient pharmacological inhibition of succinate dehydrogenase (SDH) with malonate promotes regeneration after myocardial infarction. Here, we integrat...

Yi Fan, Dakota J. Nuttall, Yi Zhao et al. · Nature Cardiovascular Resear... · 0 citations

Open access Jul 2026

Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming

It is shown that the sulfotransferase CHST7 stabilizes fibroblast fate via CD44/JUNB signalling, and that its inhibition enhances cardiac reprogramming and improves heart repair, and defines a sulfotransferase-dependent barrier to cell fate conversion with therapeutic implications for heart regeneration.

Michaela R. Romero, S. Murphy, Yu-Zhu Chang et al. · Nature Communications · 0 citations