Sanghwa Kim

HIF-1α-ASS1 axis drives reprogramming of arginine metabolism controls hepatic stellate cell activation in hepatic fibrosis.

Dysregulated arginine metabolism promotes hepatic stellate cell (HSC) activation and liver fibrosis. However, the mechanisms underlying arginine hosmeostasis in hepatic fibrogenesis and therapeutic targeting remain unclear. Using Multicellular hepatic spheroid (MCHS) models recapitulating in vivo liver fibrosis, we inv...