Open access
Oct 2026
PTHrP induces breast cancer bone metastases via microbial-dependent expansion of TNF/IL-17-producing T cells.
Bone metastases are a frequent complication of breast cancer, leading to reduced quality of life and increased morbidity. By intratibially injecting PyMT breast cancer cells in mice, we showed that the presence in the gut microbiome of segmented filamentous bacteria (SFB), a taxon that induces IL-17-producing Th17 cell...
N. K. Roy, Subhashis Pal, Hamid Y. Dar et al.
· JCI Insight · 0 citations