Acute cardiovascular care is among the most resource-intensive domains of contemporary healthcare. Major investments are concentrated in the index hospital episode, including emergency diagnostics, reperfusion or revascularization, intensive monitoring, specialist pharmacotherapy and multidisciplinary stabilization. Ye...
P. Boettger, A. Matetić, T. Kinsley et al.· Health Economics and Policy· 0 citations
TMEM70 variants represent the most common nuclear cause of mitochondrial ATP synthase (Complex V) deficiency and are associated with particularly severe cardiac manifestations. Yet, how TMEM70 deficiency disrupts cardiomyocyte metabolic maturation and function remains poorly understood, in part because suitable human d...
Esteban Palacios-Contreras, Karen An der Brügge, J. Fell et al.· bioRxiv· 0 citations
Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain cause DCM with (R634L) or without (R634W) left ventricular non-compaction (LVNC). However, the mechanisms underlying pheno...
S. Rebs, F. Sedaghat-Hamedani, E. Kayvanpour et al.· Signal Transduction and Targ...· 0 citations
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