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Samuel Eriksson Lidbrink

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Open access Apr 2026

Several multiple sequence alignment-perturbing methods enhance AlphaFold3 sampling of alternative protein states

Protein function often involves multiple conformational states. Several multiple sequence alignment-perturbing strategies, including stochastic subsampling, clustering, and column masking, have been shown to enhance AlphaFold2 (AF2) sampling of alternative protein states. Here, we evaluate these strategies on AlphaFold...

Samuel Eriksson Lidbrink, Ivan Nissen, Jonathan Kenichi Ahrlind et al. · bioRxiv · 0 citations

Open access Sep 2026

Molecular determinants of ligand recognition and efficacy in the TRPM3 voltage sensor-like domain

Transient receptor potential melastatin 3 (TRPM3) is a calcium-permeable ion channel implicated in chronic pain and developmental and epileptic encephalopathies. The voltage sensor-like domain (VSLD) is a major site of pharmacological modulation, but the molecular determinants of ligand recognition and efficacy remain...

Vikram Dalal, V. Rangari, Samuel Eriksson Lidbrink et al. · bioRxiv · 0 citations