Top-Down Proteomics Analysis of pg-Level Cell Lysate Using Spray-Capillary CE-FAIMS-MS
Capillary electrophoresis-mass spectrometry (CE-MS) is a promising technique for ultrasensitive top-down proteomics due to its high resolution and sensitivity compared with traditional liquid chromatography (LC)-based methods. However, CE-MS-based top-down proteomics of mass-limited samples remains challenging becaus...