Sami I. Alzarea

Rufigallol attenuates splenic damage caused by STZ by targeting oxidative stress, inflammation, and the apoptosis pathway

Ameliorative Effect of Rosinidin Against an Ethanol-induced Ulcer: Molecular Docking and Implication of PGE2/ IL-6/IL-1β/TNF-α and NF-κB Pathways.

INTRODUCTION/OBJECTIVE In this study, we assessed the antiulcer property of rosinidin on the Ethanol (EtOH)-induced ulcer. METHODS EtOH was administered orally to induce ulcers in rats. The potency of rosinidin 10 and 20 (mg/kg) was evaluated under trial with EtOH-induced gastric ulcer (EtOH 1.5 ml/animal). After ind...

Acemannan as a potential therapeutic agent for cognitive impairment via modulation of cholinergic, oxidative, and inflammatory pathways: in vivo and in silico evidence

Protective Effects of Cubebin on Neuroinflammation, Neurotransmitter Depletion, Mitochondrial Dysfunction, and Motor Disability in Parkinsonian Rats

Parkinson’s disease (PD) is an advanced neurodegenerative state with diverse degeneration of dopaminergic neurons, oxidative stress, mitochondrial dysfunction, and neuroinflammation. The present study aimed to evaluate the neuroprotective effect of cubebin against rotenone-induced Parkinsonism disability in Wistar rats...

The Microbiome-Gut-Brain Axis: Decoding the Molecular Dialogue for Next-Generation Neurotherapeutics.

A forward-looking roadmap is concluded that emphasizes multi-omics integration, standardization, human-relevant disease models, and personalized therapeutic strategies to decode the MGBA and exploit its full potential, which could revolutionize the treatment of brain disorders.

Erucic acid arbitrates neuroprotection in streptozotocin-induced memory deficit via improving oxidative stress/neuroinflammatory indicators/cholinergic activity in rodents.

BACKGROUND Erucic acid (EA), a monounsaturated omega-9 fatty acid derived from Raphanus sativus L. seeds, has antioxidant and anti-inflammatory properties. This study investigated its neuroprotective effects against streptozotocin (STZ)-induced diabetes-associated cognitive dysfunction in rats. METHODS Male Wistar ra...