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Author

Samer Saleh

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Open access Sep 2026

A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.

Noncanonical redox cofactors (NRCs) are low-cost alternatives to the natural redox cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) for biomanufacturing, offering exquisite electron-delivery control, yet their adoption is limited by the scarcity of compatible en...

Samer Saleh, Ning-Hsiang Hsu, Emma Luu et al. · 0 citations
Open access Jul 2026

Machine learning guided cell-free expression maps the biochemical landscape of carbonic anhydrase

This work demonstrates that integrating cell-free enzyme engineering with machine learning enables opportunities for high-throughput experimental measurements to benchmark and improve protein language models, accelerate design loops, and expand functional exploration within protein families where experimental informati...

J. Lazar, Evan Komp, I. Martínez et al. · 1 citation

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