Sameer N. Goyal

Systematic Development of Pregabalin-Loaded Intranasal Thermosensitive In Situ Gel: In-Vitro Characterization, Ex-Vivo Safety and In-Vivo Efficacy Assessment Against Partial Epilepsy

Plumbagin reduces anger-like phenotype in rats by suppressing nitric oxide signaling and enhancing serotonergic transmission in the central nucleus of the amygdala.

Intermittent explosive disorder (IED) is characterized by impulsive outbursts of anger and violent behavior, involving dysregulation of limbic circuits underlying emotional and behavioral control. Neuronal nitric oxide synthase (nNOS)-derived nitric oxide may modulate serotonergic neurotransmission involved in anger re...

Microglial GPR56 in synaptic pruning: mechanisms, comparative receptor biology, and context-dependent roles in brain disorders.

Microglia regulate synaptic remodelling, eliminating weakened and dysfunctional synapses to maintain circuit development and homeostasis. Adhesion G protein-coupled receptor G1 (ADGRG1/GPR56) has emerged as a distinctive regulator integrating phosphatidylserine recognition, mechano-transduction, and G-protein signallin...

Integrated cellular and molecular mechanisms of neuropsychiatric dysfunction in polycystic ovary syndrome.

Neuropsychiatric conditions such as depression, anxiety, and stress-related disorders are increasingly associated with Polycystic Ovary Syndrome (PCOS). Evidence suggests that these conditions are not only linked to the metabolic features of PCOS but also share common underlying mechanisms, including hormonal imbalance...

Memantine modulates TRPM3-associated glutamatergic signaling via vGLUT2 in a mouse model of obsessive-compulsive disorder.

Findings support a novel TRPM3-vGLUT2-NMDA signaling axis in OCD and suggest memantine and primidone as promising candidates for targeted, mechanism-based therapy.