A Hox-dependent anchoring mechanism mediates transcriptional repression of autophagy-related genes at the nuclear periphery
The spatial organization of the genome within the nucleus is critical for gene regulation, yet the mechanisms by which transcription factors (TFs) orchestrate this process remain poorly understood. Here, we demonstrate that the Drosophila Hox protein Ultrabithorax (Ubx) represses autophagy-related (atg) genes by tether...