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Author

Salvatore Villani

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Open access Jul 2026

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP‑2 Signaling

Compound 66 represents a chemical probe for dissecting enzymatic and signaling functions within the IDO1/TDO axis and supports small-molecule modulation of both catalytic and noncatalytic immune-metabolic pathways as an alternative to purely catalytic IDO1 inhibition or complete IDO1 degradation.

Sarah Jane Rezzi, Andrea Butticè, Salvatore Villani et al. · 0 citations

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