Aug 2026
Protective Effects of Icariin-Loaded Nanoliposomes against Methotrexate-Induced Testicular Toxicity via Modulation of NRF2/NF-κB and Ferroptosis Signaling.
ICA-loaded nanoliposomal formulation effectively attenuated MTX-induced testicular toxicity and was associated with reduced oxidative stress, inflammation, apoptosis, and ferroptosis, highlighting its potential as a promising therapeutic strategy for preserving male reproductive function.
Ahmed Al-Emam, Salim Jamil, Hesham M Hassan et al.
· Reproductive Toxicology · 0 citations