FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF A CELLULOSE DERIVATIVE-BASED MATRIX SYSTEM FOR EXTENDED-RELEASE METFORMIN USING RESPONSE SURFACE METHODOLOGY
This study aimed to develop and optimize an extended-release (ER) metformin hydrochloride matrix tablet using hypromellose as the matrix-forming polymer. ER formulations of metformin are crucial as they provide stable plasma concentrations, reduce dosing frequency and gastrointestinal side effects, enhancing patient ad...