Saleha Nayab

Computational Analysis of Wild-Type and I143T Mutant PSEN1: Molecular Docking Reveals Reduced PC1 Ligand Binding Affinity in Early-Onset Familial Alzheimer's Disease

Background: Presenilin-1 (PSEN1) mutations are frequently associated with early-onset familial Alzheimer's disease (EOAD), a progressive neurodegenerative disorder. The PSEN1 I143T variant has been implicated in disease pathogenesis; however, its potential structural and molecular effects on ligand binding require furt...