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Sakdiphong Punpai

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2 papers indexed here

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Open access Sep 2026

Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive in silico docking and in vitro study

Colorectal cancer (CRC) is closely associated with chronic inflammation, and the NF-κB pathway acts as a central regulator of the inflammatory response that promotes tumor progression. In this study, we examined the anticancer and anti-inflammatory potential of anilino-1,4-naphthoquinone derivatives (compounds 3, 8, an...

Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat et al. · 0 citations
Open access Sep 2026

Anilino-1,4-naphthoquinone derivatives exhibit antiproliferative, anti-inflammatory, and pro-apoptotic activities in LPS-stimulated SW480 colorectal cancer cells: In vitro and in silico studies.

Findings establish compound 12 as a promising lead candidate for the development of new anti-colorectal cancer agents and provide mechanistic insights into the interplay between COX-2 inhibition, inflammatory modulation, and apoptosis induction in inflammation-associated colorectal carcinogenesis.

Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat et al. · 0 citations

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