Forsythiaside B alleviates DOX-induced myocardial injury by enhancing the interaction between HSP90AA1 and CYP1A1 to inhibit ferroptosis.
BACKGROUND Doxorubicin (DOX) is a potent anti-tumor drug that is commonly associated with cardiotoxic reactions (DIC) during its use. Ferroptosis in cardiomyocytes is one of the key pathogenic mechanisms of this toxic reaction. Forsythiaside B (FTB) has been proven to have cardioprotective effects, but its role and pot...