Beyond Nucleosome Assembly - Chromatin Assembly Factor 1 as a Nexus of Genome Stability Cell Identity and Cancer
Chromatin assembly factor 1 (CAF-1) is an evolutionarily conserved histone chaperone complex that deposits newly synthesized histones H3-H4 onto nascent DNA. By coupling DNA synthesis to nucleosome assembly, CAF-1 restores chromatin after replication and repair, supports epigenetic inheritance, and helps maintain cellu...