Sai Madhuri Sedam

An Integrated Approach Combining Receptor-Based Ensemble Screening and In Vivo Phenotypic Assessment Improves Drug-Induced Liver Injury Prediction

Inhibition of ABCB11, also called the Bile Salt Export Pump (BSEP), is closely linked to cholestatic drug-induced liver injury (DILI). ABCB11 undergoes large-scale conformational changes during its catalytic turnover, making it challenging to incorporate this flexibility into large-scale structure-based screening. He...