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Sahar Heidari

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Oct 2026

Decoding Conformational Dynamics and Hyperactivity of Histone H3K36 N -Methyltransferase in Oncogenic Mutations via tICA and Markov State Modeling

NSD2 is a histone methyltransferase that modifies lysine 36 in histone H3 (H3K36), playing a central role in chromatin organization and transcriptional regulation. Oncogenic mutations, such as E1099K and T1150A in NSD2, have been associated with hyperactive methylation, but the molecular mechanisms underlying this ga...

Tejas Shah, Sahar Heidari, J. Rydzewski et al. · 0 citations

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