Author

Sagar

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Open access Oct 2026

Fenofibrate enhances systemic antitumor efficacy of high- and low-dose radiotherapy plus PD-1 blockade through CD8+ T-cell metabolic reprogramming and LDRT tumor conditioning.

Radiotherapy (RT) combined with PD-1/PD-L1 blockade can induce systemic antitumor responses, but robust control of distant lesions remains uncommon. We identified a quadruple regimen combining immunogenic hypofractionated RT (hRT; 8 Gy × 3) to the primary tumor, low-dose RT (LDRT; 3 Gy × 3) to the secondary tumor, anti...

Mei-Dan Wang, Li-Qun Wang, Sagar et al. · Cancer Letters · 0 citations

Open access Aug 2026

Memory T Cells in MHC-Deficient Humanized Mice

This work investigated how elimination of murine MHC together with different conditioning regimens shapes human T-cell maturation in vivo, and revealed marked differences in T-cell differentiation across models.

M. Darguzyte, Ж. Ш. Жумадилова, F. Khan et al. · bioRxiv · 0 citations

Open access Aug 2026

Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity, and tissue homeostasis. While their feta...

D. Obwegs, Alexander Oschwald, L. Koetter et al. · Science Advances · 0 citations