Thiolactomycin-based morpholino and piperidino conjugates: synthesis, antimalarial evaluation, and PfFAS-II inhibition
Background and purpose: Malaria remains a formidable global healthcare challenge due to emerging drug-resistant Plasmodium spp., underscoring the urgent need for novel antimalarial scaffolds. Thiolactomycin, a FAS-II inhibitor, is a promising lead for structural optimization. This study aims to design, synthesize, and...