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Review Sep 2026

The splicing axis of aging: mechanisms and therapeutic opportunities.

Aging is characterized by progressive loss of molecular fidelity that compromises stem-cell function and tissue homeostasis. Aging transcriptomes show widespread disruption of RNA processing, including increased intron retention, cryptic splice-site usage, and altered RNA quality control. These changes arise from somat...

Sada Raza, Ankita Kumari, Maciej Cieśla · 0 citations

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