Risk assessment of oral exposure to cyclic siloxanes - octamethylcyclotetrasiloxane (D4) as an example.
Published data on in vivo toxicity of octamethylcyclotetrasiloxane (D4) on rat kidneys was re-evaluated. It turned out that a molecular and biochemical mode of action (MOA) of D4 induced effects on kidneys and its human relevance is missing, which remains a gap in current knowledge. Increased kidney weights (also in re...