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[This corrects the article DOI: 10.3389/fphar.2024.1491249.].
Integrated in silico and in vivo studies confirmed the hepatoprotective effect of calycosin against the EILI rat model and provided a mechanistic insight through TNF-α/NF-κB/HIF-1α signaling.
The mouse experiment showed that hesperetin prevented the decrease hematological parameters, enhanced the bone marrow cellularity to 80%–90%, and the splenic architecture, and that hesperetin is an interesting complementarity with the TLR4/MD2 interface which was a good rationale for the experimental validation.
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