Abstract PR006: Activated ALK and MYCN drive neuroblastoma initiation through tissue-specific dynamics of neuroblast persistence and transformation
Neuroblastoma (NB) is an embryonal malignancy of the sympathetic nervous system that arises in either the adrenal gland or sympathetic ganglia. However, its developmental origin and the earliest steps of tumor initiation remain incompletely understood. We investigated how ALK activating mutations and MYCN overexp...