Open access
Jul 2026
Additive framework of hormonal waves accounts for species and age differences in circadian intraocular pressure rhythm
A minimal mathematical framework in which IOP rhythms arise from the linear superposition of two sinusoidal signals: adrenal glucocorticoids and norepinephrine from the superior cervical ganglion is developed, which provides a unifying conceptual basis for the circadian regulation of IOP across species and may inform novel diagnostic algorithms and chronotherapeutic strategies for glaucoma.
Keisuke Ikegami, Ryo Fujie, Fumito Mori et al.
· npj Biological Timing and Sl... · 0 citations