Author

S. Wied

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Open access Sep 2026

Does randomization matter in rare disease clinical trials

Background Conducting Rare Disease Clinical Trials poses a wide variety of research challenges. Many techniques that are usually considered the best standard for evaluating new therapies are more difficult to implement here. This also holds in terms of randomization in clinical trials. The question arises how to random...

S. Wied, Denis Kirilov Razsolkov, Nicole Heussen et al. · PLoS ONE · 0 citations

Open access Sep 2026

Spinal versus general anaesthesia and serious complications in older patients undergoing hip fracture surgery in Germany: a multicentre randomised clinical trial.

BACKGROUND Evidence on the optimal anaesthetic technique for hip fracture surgery is scarce. We evaluated the effects of spinal versus general anaesthesia on all-cause mortality and new-onset serious cardiac and pulmonary complications in older patients undergoing hip fracture surgery. METHODS We conducted the pragma...

A. Kowark, Stefanie Schoenen, Rene Schmidt et al. · The Lancet Healthy Longevity · 1 citation