Author

S. Viswanathan

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Open access Sep 2026

BCL-XL dependence is a subtype agnostic actionable feature of difficult-to-treat kidney cancers

BCL-X L is a BCL-2 family anti-apoptotic protein that functions as a targetable dependency in clear cell Renal Cell Carcinoma (ccRCC), the most common form of adult kidney cancer. However, the mechanisms driving this dependence are unclear. Moreover, although significant strides have been made in managing ccRCC,...

Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan et al. · Cell Death & Disease · 0 citations

Open access Aug 2026

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Renal cell carcinomas (RCC) comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes and chromatin accessibility profile...

Prathyusha Konda, Alexandra J. Wakolbinger, Yan-Tong Cui et al. · Nature Communications · 0 citations

Jul 2026

Abstract PR006: Target discovery in rare cancers enabled by transcriptome-based virtual CRISPR screening

It is demonstrated that machine learning applied to transcriptomic data can uncover novel cancer vulnerabilities and actionable targets in individual tumors, even in the absence of functional screening, which may represent a scalable approach to advance precision oncology in rare and/or under-characterized cancer types...

Ananthan Sadagopan, Bingchen Li, Jiao Li et al. · Cancer Research · 0 citations