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Open access Aug 2026

Mechanical Suppression of Sonic Hedgehog Signaling by Nucleus Pulposus Cells Underlies Early Disc Degeneration in Mouse

Sonic hedgehog (SHH) expression by nucleus pulposus (NP) cells is important for intervertebral disc development and maintenance. The lumbosacral disc, the most immobile region of the spine, lies adjacent to the sacrum and is most vulnerable to degeneration. We hypothesized that a lack of mobility represses SHH expressi...

S. Virk, Veeraj Shah, Vikrant Piprode et al. · 0 citations
Open access Sep 2026

Preoperative step count as a predictor of early postoperative mobility and patient-reported outcomes following lumbar spine surgery

ABSTRACT Objectives: Objective activity monitoring may provide scalable, real-world functional data in lumbar spine surgery patients. We evaluated whether preoperative daily step count predicts early postoperative ambulation and patient-reported outcomes (PROs). Materials and Methods: We performed a retrospective cohor...

Jun-Ho Song, Austen D. Katz, Timothy Hoang et al. · 0 citations

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