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S. Vianello

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Open access Aug 2026

Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids

A single-cell CRISPR screening platform is established in gastruloids to identify Cnot8-dependent mRNA deadenylation as a driver of mesoderm patterning and identify the deadenylase Cnot8 as a fundamental mechanism linking cellular identity with morphogenetic signaling during mammalian body plan formation.

D. Taborsky, Fabiola Valdivia-Francia, Pablo Serrano et al. · 0 citations

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