Antiretroviral therapy suppresses HIV-1 replication but cannot eliminate the latent viral reservoir persisting in memory CD4 T cells. Existing latency reversal candidates have yet to achieve robust viral reactivation at tolerable doses. We engineered T4IL15Δ, a bispecific biologic that selectively delivers IL-15 signal...
Yao-Xing Huang, M. Nair, Jian Yu et al.· bioRxiv· 0 citations
Seropositivity was 5.5% in a high-risk cohort of people living with human immunodeficiency virus in Bangkok during 2022, suggesting unrecognized transmission occurred months before the official outbreak.
E. Co, Paramate Promnarate, M. Imbach et al.· IJID Regions· 0 citations
It is found that the accumulation of mutations was slower than expected, implying a selection against HIV-1 diversification in acute infection, potentially leaving a window of low genetic diversity for the study of new interventions towards inducing viremic control, such as immunotherapy or mRNA vaccination.
A. Capoferri, V. Boltz, W. Shao et al.· bioRxiv· 0 citations
A dynamic CD8+ T cell state continuum is identified as a central determinant of HIV-1 rebound, even in the absence of antigen-specificity, where ART establishes a predictive poised naïve state that can be further leveraged by vaccination to enhance protective stem-like memory responses.
Jie Wang, Gautam Kundu, P. Ehrenberg et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
