Author

S. Tullius

2 papers indexed here

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Open access Sep 2026

Transplanted hearts assimilate the recipient’s biological age

Background Despite the growing demand for transplantation, a shortage of donor organs persists, limiting access to this lifesaving procedure. To meet the increasing demand, organs are frequently transplanted across an age discrepancy between donor and recipients. Methods We delineated biological age dynamics in heteroc...

J. Poganik, Tomohisa Matsunaga, A. Tyshkovskiy et al. · bioRxiv · 0 citations

Open access Sep 2026

Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction.

Senescent cells, which are normally cleared by the immune system but accumulate with age, contribute to multiple disorders including metabolic dysfunction and impaired fitness. While immune checkpoint inhibitors have been well studied in cancer, the role of programmed cell death ligand 2 (PD-L2) in non-cancerous, age-a...

Selim Chaib, Larissa P. G. Langhi Prata, Masayoshi Suda et al. · Cell Metabolism · 0 citations